When I last saw Derek (Ben Stiller) and Hansel (Owen Wilson), enjoy the wonderful “Derek Zoolander Center for Kids who can not read well and want to learn to do other good things” and Mugatu (Will Ferrell) was behind bars. An unexpected disaster strikes the center and forcing the two to hide. Fifteen years later we find Derek and Hansel and separate living isolated lives, away from the world.
When both receive an invitation to appear at a fashion event in Rome ancient and mysterious city, I can not resist the temptation to return to their former glory and return to civilization. Upon arrival, Derek and Hansel and bizarii meet his eccentric designers who are behind fashion empire. The two quickly realize that the fashion world that once knew has changed drastically.
While struggling to find relevance in the strange world filled with blogging, Vlogging, and fashion anti-fashion, are recruited to help stop a plan calculated and deadly, if not stopped, would destroy forever the hopes that fashion to return to its glorious status and revered. Derek and Hansel only have the power to save fashion.